top of page

Ergo Group

Public·19 members
Ryan Hill
Ryan Hill

Learn Pharmaceutics with RM Mehta's Book: Download PDF for Free


Pharmaceutics 1 by RM Mehta: A Comprehensive Guide for Pharmacy Students




Pharmaceutics is the science that deals with the design, development, manufacture, delivery, evaluation, and use of drugs in various dosage forms. It is one of the core subjects for pharmacy students, as it provides them with the necessary knowledge and skills to formulate effective, safe, stable, and acceptable drug products for various therapeutic purposes.




pharmaceutics1rmmehtapdfdownload



One of the best books for learning pharmaceutics is Pharmaceutics - I by R.M. Mehta, a renowned author and professor in the field. This book covers all the essential topics related to pharmaceutics in a clear, concise, and comprehensive manner. It is divided into eleven chapters, each focusing on a different type or aspect of pharmaceutical dosage forms. The book also includes numerous examples, illustrations, tables, diagrams, and exercises to enhance the understanding and application of the concepts.


In this article, we will provide an overview of each chapter in the book, highlighting the main points and features that make this book a valuable resource for pharmacy students. We will also provide some frequently asked questions about the book or the topic at the end.


Chapter 1: Introduction to Pharmaceutics




This chapter introduces the basic concepts and principles of pharmaceutics, such as:



  • The definition and scope of pharmaceutics as a science and an art.



  • The classification of dosage forms based on their physical state (solid, liquid, or gas), route of administration (oral, topical, parenteral, etc.), or release mechanism (immediate, modified, or controlled release).



  • The factors affecting drug absorption, distribution, metabolism, and excretion (ADME) in the body, such as drug solubility, stability, partition coefficient, pH, ionic strength, bioavailability, etc.



The chapter also explains the importance of pharmacokinetics and pharmacodynamics in designing optimal dosage regimens for different drugs and patients.


Chapter 2: Pharmaceutical Solutions




This chapter deals with one of the simplest and most common types of dosage forms: solutions. It covers topics such as:



  • The definition and types of solutions (true, colloidal, or coarse), based on their particle size and degree of dispersion.



  • The methods of preparation and quality control of solutions, such as filtration, clarification, sterilization, preservation, etc.



  • The solubility and factors affecting solubility (temperature, pressure, polarity, pH, etc.)



The chapter also discusses some special types of solutions, such as syrups, elixirs, tinctures, spirits, etc., along with their advantages and disadvantages.


Chapter 3: Suspensions and Emulsions




This chapter deals with two types of dispersed systems: suspensions and emulsions. It covers topics such as:



  • The definition and types of suspensions (coarse or fine) and emulsions (oil-in-water or water-in-oil), based on their phase ratio and droplet size.



  • The methods of preparation and quality control of suspensions and emulsions, such as levigation, trituration, flocculation, homogenization, etc.



  • The stability and rheology of suspensions and emulsions, such as sedimentation rate, viscosity, thixotropy, etc.



The chapter also explains some important concepts such as zeta potential, Ostwald ripening, creaming, coalescence, etc., that affect the stability and performance of suspensions and emulsions.


Chapter 4: Powders and Granules




This chapter deals with another type of solid dosage form: powders and granules. It covers topics such as:



  • The definition and types of powders (simple or compound) and granules (effervescent or non-effervescent), based on their composition or function.



  • The methods of preparation and quality control of powders and granules, such as comminution, sieving, blending, granulation, drying, etc.



  • The advantages and disadvantages of powders and granules over other dosage forms.



The chapter also discusses some special types of powders and granules, such as dusting powders, insufflations, cachets, capsules, etc., along with their applications and limitations.


Chapter 5: Semisolid Dosage Forms




This chapter deals with one of the most widely used topical dosage forms: semisolid dosage forms. It covers topics such as:



  • The definition and types of semisolid dosage forms (ointments or creams), based on their consistency or composition.



  • The methods of preparation and quality control such as fusion, levigation, incorporation, etc.



  • The application and evaluation of semisolid dosage forms, such as spreadability, penetration, drug release, etc.



The chapter also explains the role of various excipients such as bases, emulsifiers, preservatives, antioxidants, etc., in modifying the properties and performance of semisolid dosage forms.


Chapter 6: Suppositories and Pessaries




This chapter deals with two types of solid dosage forms that are intended for insertion into body cavities: suppositories and pessaries. It covers topics such as:



  • The definition and types of suppositories (rectal or vaginal) and pessaries (vaginal or uterine), based on their shape or location.



  • The methods of preparation and quality control of suppositories and pessaries, such as molding, compression, extrusion, etc.



  • The factors affecting drug release from suppositories and pessaries, such as base type, melting point, dissolution rate, etc.



The chapter also discusses some advantages and disadvantages of suppositories and pessaries over other dosage forms.


Chapter 7: Tablets




This chapter deals with one of the most popular and versatile types of solid dosage forms: tablets. It covers topics such as:



  • The definition and types of tablets (uncoated or coated), based on their shape, size, or coating.



  • The methods of preparation and quality control of tablets, such as wet granulation, dry granulation, direct compression, etc.



  • The coating and evaluation of tablets, such as sugar coating, film coating, enteric coating, etc.



The chapter also explains the role of various excipients such as diluents, binders, disintegrants, lubricants, glidants, etc., in modifying the properties and performance of tablets.


Chapter 8: Capsules




This chapter deals with another type of solid dosage form: capsules. It covers topics such as:



  • The definition and types of capsules (hard or soft), based on their shell material or content.



  • The methods of preparation and quality control of capsules, such as filling machines, weighing machines, sealing machines, etc.



  • The filling and sealing of capsules, such as powder filling, pellet filling, liquid filling, etc.



The chapter also discusses some advantages and disadvantages of capsules over other dosage forms.


Chapter 9: Parenteral Dosage Forms




This chapter deals with one of the most critical and complex types of dosage forms: parenteral dosage forms. It covers topics such as:



  • The definition and types of parenteral dosage forms (injections or infusions), based on their route of administration (intravenous, intramuscular, subcutaneous, etc.), volume (small or large), or formulation (solution, suspension, emulsion, etc.).



  • The methods of preparation and quality control of parenteral dosage forms, such as sterilization methods (heat, filtration, radiation, etc.), aseptic techniques (laminar flow hood, gloves, gowns, etc.), pyrogen testing (rabbit test, limulus amebocyte lysate test, etc.), etc.



  • The sterilization and packaging of parenteral dosage forms, such as ampoules, vials, syringes, cartridges, etc.



The chapter also explains the importance of compatibility and stability of parenteral dosage forms and the factors affecting them.


Chapter 10: Ophthalmic Dosage Forms




This chapter deals with one of the most sensitive and specialized types of dosage forms: ophthalmic dosage forms. It covers topics such as:



  • The definition and types of ophthalmic dosage forms (drops or ointments), based on their formulation or application.



  • The methods of preparation and quality control of ophthalmic dosage forms, such as sterilization methods (filtration, autoclaving, etc.), isotonicity adjustment (sodium chloride equivalent method, freezing point depression method, etc.), preservative selection (benzalkonium chloride, chlorobutanol, etc.), etc.



  • The application and evaluation of ophthalmic dosage forms, such as instillation technique (tilt head back, pull lower eyelid down, etc.), bioavailability measurement (fluorophotometry, radioisotope method, etc.), etc.



The chapter also discusses some special types of ophthalmic dosage forms, such as contact lens solutions, ocular inserts, ocular implants, etc., along with their advantages and disadvantages.


Chapter 11: Aerosols




This chapter deals with one of the most innovative and convenient types of dosage forms: aerosols. It covers topics such as:



  • The definition and types of aerosols (pressurized or non-pressurized), based on their propellant system or formulation.



  • The methods of preparation and quality control of aerosols, such as cold filling method, pressure filling method, etc.



  • The propellants, valves, containers, actuators, etc. for aerosols and their functions and selection criteria.



The chapter also explains the advantages and disadvantages of aerosols over other dosage forms and the factors affecting their performance and stability.


Conclusion